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About This Item
Empirical Formula (Hill Notation):
C15H11ClF3NO
CAS Number:
Molecular Weight:
313.70
MDL number:
NACRES:
NA.21
SMILES string
O=C(C1=CC=CC=C1NC2=CC(C(F)(F)F)=CC=C2)CCl
assay
≥98% (HPLC)
form
powder
Quality Level
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
TED-347is a potent and selective allosteric inhibitor of the transcriptional enhanced associate domain (TEAD)-yes-associated protein 1 (Yap1) protein-protein interaction (EC50 =5.9 µM) that inhibits TEAD transcriptional activity. It potentlyinhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines.TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond withCys-367.
Application
TED-37 is used to probe the how dyregulation ofYAP-TEAD signalling relates to glioblastoma proliferations.
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