SML4158
TED-347
≥98% (HPLC)
Synonym(s):
2-Chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]ethanone
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About This Item
Empirical Formula (Hill Notation):
C15H11ClF3NO
CAS Number:
Molecular Weight:
313.70
MDL number:
UNSPSC Code:
12352200
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C1=CC=CC=C1NC2=CC(C(F)(F)F)=CC=C2)CCl
Related Categories
General description
TED-347is a potent and selective allosteric inhibitor of the transcriptional enhanced associate domain (TEAD)-yes-associated protein 1 (Yap1) protein-protein interaction (EC50 =5.9 µM) that inhibits TEAD transcriptional activity. It potentlyinhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines.TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond withCys-367.
Application
TED-347 is used to probe the how dysregulation ofYAP-TEAD signalling relates to glioblastoma proliferations
Biochem/physiol Actions
Potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction that inhibits TEAD transcriptional activity.
TED-347 is a potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction (EC50 = 5.9 µM) that inhibits TEAD transcriptional activity. TED-347 potently inhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines. TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond with Cys-367.
TED-347 is a potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction (EC50 = 5.9 µM) that inhibits TEAD transcriptional activity. TED-347 potently inhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines. TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond with Cys-367.
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