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SML4159

AU-15330

Name: AU-15330
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

(2S,4R)-1-[(2S)-2-(2-{4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):

C₃₉H₄₉N₉O₅S

CAS Number:

2380274-50-8

Molecular Weight:

755.93

MDL number:

MFCD35063364

NACRES:

NA.21

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N(CC3)CCN3CC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(N=CS6)C)C=C5)C)=O)=O)=O

Description

Application

AU-15330 may be usedin molecular biology and cancer research applications.

Biochem/physiol Actions

AU-15330 is a highly-selective proteolysis-targeting chimera (PROTAC) degrader of both SWItch/SucroseNon-Fermentable (SWI/SNF) adenosine triphosphatase (ATPase) subunits— SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 & 4 SMARCA2 (BRM)and SMARCA4 (BRG1) SWI/SNF ATPases. It potently inhibits tumor growth in xenograft models of prostate cancer. AU-15330 comprises a bait moiety that binds the bromodomain in SMARCA2 and SMARCA4 and a ligand moiety for the von Hippel–Lindau (VHL) ubiquitin ligase. It synergized with the androgen receptor antagonist enzalutamide.

pictograms

GHS07

signalword

Warning

hcodes

H302,H315

pcodes

P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364

Hazard Classifications

Acute Tox. 4 Oral - Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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