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SML4168

Ceftobiprole Medocaril sodium

≥95% (HPLC)

Synonym(s):

(6R,7R)- 7-[[(2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(hydroxyimino)acetyl]amino]-3-[(E)-[(3′R)-1′-[[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl]-2-oxo[1,3′-bipyrrolidin]-3-ylidene]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt, BAL 5788, BAL 5788-001, Ro 65-5788, sodium (6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetamido)-3-((E)-((R)-1′-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2-oxo-[1,3′-bipyrrolidin]-3-ylidene)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C26H25N8NaO11S2
CAS Number:
252188-71-9
Molecular Weight:
712.64
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

Biochem/physiol Actions

Ceftobiprole medocaril, a water-soluble prodrug converted by plasma esterases to ceftobiprole (SML3638), is a 5th-generation cephalosporin with broad-spectrum efficacy against both Gram-positive bacteria, such as MRSA, penicillin-resistant Streptococcus pneumoniae, and Enterococcus faecalis, and Gram-negative bacteria, including Pseudomonas aeruginosa and a majority of enterobacteria. Ceftobiprole mechanism of action involves inhibiting bacterial growth by binding to penicillin-binding proteins, disrupting cell wall synthesis. While ceftobiprole medocaril is effective against certain anaerobes like Clostridium spp. and Fusobacterium spp., it lacks activity against microorganisms responsible for atypical pneumonia and is ineffective against bacteria that express certain carbapenemases or β-lactamases, including metallo-carbapenemases and extended-spectrum beta-lactamases (ESBLs).

Disclaimer

Hygroscopic, store with desiccant

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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