Quality Segment
assay
≥95% (Gadolinium, elemental analysis)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
OC[C@H](N1CCN(CCN(CC([O-])=O)CCN(CC([O-])=O)CC1)CC([O-])=O)[C@@H](O)CO.[Gd+3]
General description
Gadobutrol is a highly water-soluble, macrocyclic, and electrically neutral gadolinium-based contrast agent (GBCA) used in contrast-enhanced MRI. Its active component is a non-ionic, paramagnetic complex of gadolinium (Gd3+) chelated with butrol, forming the distinct gadobutrol structure. Gadobutrol exhibits the greatest shortening of proton T1 relaxation times amongst all macrocyclic GBCAs, a key determinant of signal and contrast enhancement in MRI.
Application
Gadobutrol may be used to enhance diagnostic contrast in magnetic resonance imaging (MRI) of pathological lesions in the liver, central nervous system (CNS), kidney, and brain.
Biochem/physiol Actions
Water-soluble macrocyclic gadolinium-based MRI contrast agent excreted renally, enhances CNS pathology detection by improving blood-brain barrier visualization.
Upon intravenous administration, it enhances MRI sensitivity for detecting CNS pathologies associated with blood-brain barrier defects, areas of altered perfusion, or expanded extracellular space. This agent is particularly effective in visualizing tumors, inflammatory processes, and demyelinating diseases of the CNS. Gadobutrol is eliminated unchanged via the kidneys, with negligible extra-renal excretion.
Upon intravenous administration, it enhances MRI sensitivity for detecting CNS pathologies associated with blood-brain barrier defects, areas of altered perfusion, or expanded extracellular space. This agent is particularly effective in visualizing tumors, inflammatory processes, and demyelinating diseases of the CNS. Gadobutrol is eliminated unchanged via the kidneys, with negligible extra-renal excretion.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable