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SML4205

I-BET787

Name: I-BET787
Brand: SIGMA

≥98% (HPLC), powder, pan-BET bromodomain inhibitor

Synonym(s):

5-[4-Chloro-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-imidazol-2-yl]-1,3-dimethyl-2(1H)-pyridinone, 5-(4-Chloro-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazole-2-yl)-1,3-dimethylpyridin-2(1H)-one

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₀ClN₃O₂

CAS Number:

2201082-98-4

Molecular Weight:

321.80

NACRES:

NA.21

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Description

Biochem/physiol Actions

Orally active, potent and selective pan-BET family bromodomain (BrD) inhibitor. I-BET787 is an orally active, potent and selective pan-BET bromodomain (BrD) inhibitor (BRD2/3/4/T pIC50 =6.9/7.1/7.1/6.3/BrD1 5.7/6.2/5.9/5.1/BrD2) that demonstrates efficacy in an inflammation model in mice in vivo (5 & 15 mg/kg b.i.d. p.o. for 14 days)by suppressing KLH-TNP (100 μg/kg via i.p. 1h post first I-BET787 oral dosing)-induced T-cell activation.

pictograms

GHS07

signalword

Warning

hcodes

H302,H317

pcodes

P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1B

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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