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SML4206

DMXAA sodium salt

≥98% (HPLC)

Synonym(s):

5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid sodium salt; sodium 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetate, 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid sodium salt; 5,6-Dimethylxanthenone-4-acetic acid sodium salt, Vadimezan sodium salt, ASA404 sodium salt, NSC 640488 sodium salt

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About This Item

Empirical Formula (Hill Notation):
C17H13NaO4
CAS Number:
129095-08-5
Molecular Weight:
304.27
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

A water-soluble sodium salt form of DMXAA. DMXAA directly binds to murine STING (stimulator of interferon genes) but does not affect human STING. DMXAA disrupts tumor vasculature by inducing endothelial cell apoptosis, causing tumor hemorrhagic necrosis and ischemia, releasing serotonin, stimulating the innate immune system, producing inflammatory cytokines (e.g., TNF, IL-6, GCSF, KC, IP-10, MCP-1), activating NF-κB and p38 MAPK, producing nitric oxide, and reducing tumor energetics and membrane turnover.

Disclaimer

Hygroscopic Store with desiccant

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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