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About This Item
Empirical Formula (Hill Notation):
C13H17NO4
CAS Number:
Molecular Weight:
251.28
NACRES:
NA.21
SMILES string
C[C@@H](O)CC(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
BHB-Phe is a β-Hydroxybutyrate (BHB) secondary metabolite present inhuman and mouse plasma. It is a ketosis-induciblestructural and functional congener of lactate-phenylalanine.
Application
BHB-Phe may be used for examining its effects onmetabolic pathways during states of ketosis and studying its interactions withthe carnosine dipeptidase 2 (CNDP2) enzyme.
Biochem/physiol Actions
BHB-Phe exhibits anti-obesity activities hence reducing food intake and body weight in diet-induced obese (DIO) mice. Apparently BHB-Pheactivates hypothalamic and brainstem neurons and suppresses feeding. BHB-Phe issynthesized in the body by catalytic condensation of BHB and Phenylalanine by carnosine dipeptidase 2 (CNDP2).
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Maria Dolores Moya-Garzon et al.
Cell, 188(1), 175-186 (2024-11-14)
β-Hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve the interconversion of BHB and primary energy intermediates. Here, we identify a previously undescribed BHB secondary metabolic pathway via CNDP2-dependent enzymatic conjugation of BHB
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