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SML4225

Eravacycline hydrochloride

≥98% (HPLC)

Synonym(s):

N-[(5aR,6aS,7S,10aS)-9-(Aminocarbonyl)-7-(dimethylamino)-4-fluoro-5,5a,6,6a,7,10,10a,12-octahydro-1,8,10a,11-tetrahydroxy10,12-dioxo-2-naphthacenyl]-1-pyrrolidineacetamide hydrochloride, 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline hydrochloride, TP 434-046 hydrochloride, TP-434 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C27H31FN4O8 · xHCl
Molecular Weight:
558.56 (free base basis)
MDL number:
MFCD31010183
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

General description

Eravacycline, a synthetic fluorocycline antibiotic, belongs to the tetracyclines class. It is structurally similar to tigecycline, featuring two modifications on the D-ring of its tetracycline core: a fluorine atom substitutes the dimethylamine group at position C-7, and a pyrrolidinoacetamido group replaces the 2-tertiary-butyl glycylamido at position C-9.

Application

Eravacycline hydrochloride may be used as a model for studying antibiotic resistance and the development of new antimicrobial agents.

Biochem/physiol Actions

Eravacycline is a tetracycline class antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the incorporation of amino acid residues into elongating peptide chains. Its structural modifications allow it to maintain activity against bacteria that express ribosomal protection proteins and efflux pumps. Eravacycline is potent against a variety of pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae. Eravacycline demonstrates minimum inhibitory concentrations (MICs) that are two to eight times lower than those of tigecycline when tested against carbapenem-resistant Acinetobacter baumannii (CRAB).

Disclaimer

Hygroscopic Store with desiccant

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Codes

H302,H361fd

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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