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SML4232

SPC-839

≥98% (HPLC)

Synonym(s):

1-[[5-methoxy-2-(2-thienyl)-4-quinazolinyl]amino]-3-methyl-1H-pyrrole-2,5-dione, SPC 839, AS602868

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About This Item

Empirical Formula (Hill Notation):
C18H14N4O3S
CAS Number:
219773-55-4
Molecular Weight:
366.39
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

SPC-839 is a potent suppressors of T cell activation that covalently targets XPO1 at Cys 528. It potently inhibits inflammation in mice with minimal impact on nuclear export and cell viability. SPC-839 exhibits efficacy in in vivo models of autoimmune disease.

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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