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SML4264

NSC232003

≥98% (HPLC), powder, UHRF1 inhibitor

Synonym(s):

5-(1-(Hydroxyamino)ethylidene)pyrimidine-2,4(3H,5H)-dione, 5-[1-(Hydroxyamino)ethylidene]pyrimidine-2,4-dione, 5-N-Hydroxy-C-methylcarbonimidoyl]-1H-pyrimidine-2,4-dione, NSC 232003, NSC-232003

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About This Item

Empirical Formula (Hill Notation):
C6H7N3O3
CAS Number:
1905453-18-0
Molecular Weight:
169.14
MDL number:
MFCD32644067
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Application

NSC232003 may be used to investigate its effect against various cancercell lines by targeting the SRA domain of Ubiquitin-like with PHD and RINGFinger domains 1 (UHRF1).

Biochem/physiol Actions

NSC232003 is a Ubiquitin-likewith PHD and RING Finger domains 1 (UHRF1) E3 ubiquitin ligase inhibitor thatdownregulates overall genomic DNA cytosine methylation (5 mC IC50 = 15 µM post72h treatment; U251 glioma cells) by disrupting UHRF1 interaction with DNAmethyltransferase DNMT1.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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