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About This Item
Empirical Formula (Hill Notation):
C15H12N2O5S
CAS Number:
Molecular Weight:
332.33
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to gray
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
General description
Cell-permeable, selective and potent inhibitor of the FEN-1 and a chemopotentiator.
Fen1-IN-1 is a cell-permeable N-hydroxyimide compound that potently and selectively inhibits FEN-1 (Flap endonuclease 1) (IC50 = 11 nM), a divalent metal-dependent nuclear enzyme with the ability to cleave the 5′ overhang of branched dsDNA. FEN1-IN-1 minimally affects the activity of a related endonuclease xeroderma pigmentosum G (XPG; IC50 = 292 nM). Dose-dependently potentiates methyl methanesulfonate (MMS) and temozolomide-induced DNA damages in T24 bladder carcinoma cells. 20 µM of Fen1i is shown to suppress the proliferation, migration, and invasion of tumor cells.
Fen1-IN-1 is a cell-permeable N-hydroxyimide compound that potently and selectively inhibits FEN-1 (Flap endonuclease 1) (IC50 = 11 nM), a divalent metal-dependent nuclear enzyme with the ability to cleave the 5′ overhang of branched dsDNA. FEN1-IN-1 minimally affects the activity of a related endonuclease xeroderma pigmentosum G (XPG; IC50 = 292 nM). Dose-dependently potentiates methyl methanesulfonate (MMS) and temozolomide-induced DNA damages in T24 bladder carcinoma cells. 20 µM of Fen1i is shown to suppress the proliferation, migration, and invasion of tumor cells.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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