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SML4279

Validamycin A

Name: Validamycin A
Brand: SIGMA

≥95% (HPLC), powder, R. solani trehalase inhibitor

Synonym(s):

1,5,6-Trideoxy-4-O-β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol, Validamycin, Validacin, Jinganmycin A

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₃₅NO₁₃

CAS Number:

37248-47-8

Molecular Weight:

497.49

MDL number:

MFCD09028089

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

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Properties

biological source

Streptomyces hygroscopicus

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Description

General description

Validamycin A (VMA) is a fungicidal antibiotic produced by Streptomyces hygroscopicus. It is an amino glycoside compound characterized by a sugar moiety without an amino group.

Application

Validamycin A may be used for evaluating its anti-seizure effectiveness in zebrafish larval epilepsy model; and studying its potential to induce plant defense responses and controlling fungal diseases.

Biochem/physiol Actions

Validamycin A is a potent and competitive inhibitor of Rhizoctonia solani trehalase. Validamycin A is used to protect rice plants against sheath blight caused by R.solani. Validamycin A in combination with amphotericin B appears to be effective against Aspergillus flavus strains resistant to amphotericin B. It is also efficient in controlling bacterial wilt intomatoes caused by P. solanacearum.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000497936

0000497935