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About This Item
Empirical Formula (Hill Notation):
C22H15Cl3N2O2
CAS Number:
Molecular Weight:
445.73
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
ZT-1a is a potent and selective, non-ATP competitive inhibitor of SPAK-NKCC1 signaling. It inhibits SPAK activity with an IC50 of 44.3µM. Blocking the SPAK–NKCC1 cascade prevents excessive ion influx (Na⁺, K⁺, Cl⁻), which is triggered by oxidative stress. Inhibition of this pathway helps maintain cellular ion homeostasis, reduces oxidative stress-induced apoptosis, and protects the integrity of the blood–CSF barrier. Blocking SPAK–NKCC1 also mitigates neuroinflammation by reducing immune cell infiltration, thus offering neuroprotection in both in vitro and in vivo models.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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