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SML4289

Euscaphic acid

≥98% (HPLC), powder, DNA polymerase inhibitor

Synonym(s):

(2α,3α)-2,3,19-Trihydroxyurs-12-en-28-oic acid, 2α,3α,19-Trihydroxy-12-en-28-ursolic acid, Acuminatic acid, Euscophic acid, Jacarandic acid

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About This Item

Empirical Formula (Hill Notation):
C30H48O5
CAS Number:
53155-25-2
Molecular Weight:
488.70
MDL number:
MFCD09970922
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Application

Euscaphic acid may be used to study:
  • its potential in inhibiting the proliferation of non-Hodgkin lymphoma cells and other tumor types
  • its role in protecting vascular endothelial cells from hypoxia-induced apoptosis

Biochem/physiol Actions

Active component from roots of Rubus alceaefolius Poir that exhibits hepatoprotective, anti- cancer, antibiotic, and anti-inflammatory effects.
Euscaphic acid is an active component from roots of Rubus alceaefolius Poir that exhibits hepatoprotective, anti- cancer, antibiotic, and anti-inflammatory effects. Euscaphic acid potently inhibits proliferation of nasopharyngeal carcinoma by suppression of the PI3K/AKT/mTOR signaling pathway. Euscaphic acid was shown to inhibit calf DNA polymerase alpha (pol alpha) and rat DNA polymerase beta (pol beta). Recently reported to inhibit BRD4 with IC50 = 13.20 µM.
Euscaphic acid, a triterpene, is an active component from roots of Rubus alceaefolius Poir that exhibits hepatoprotective, anti- cancer, antibiotic, and anti-inflammatory effects. Euscaphic acid potently inhibits proliferation of nasopharyngeal carcinoma by suppression of the PI3K/AKT/mTOR signaling pathway. Euscaphic acid was shown to inhibit calf DNA polymerase alpha (pol alpha) and rat DNA polymerase beta (pol beta). Recently reported to inhibit BRD4 with IC50 = 13.20 µM.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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