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About This Item
Empirical Formula (Hill Notation):
C14H12ClF2NO2S
CAS Number:
Molecular Weight:
331.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
Cell penetrant, selective and potent activator of telomerase reverse transcriptase (TERT).
TAC (TERT activator compound) is a cell penetrant, selective and potent activator of telomerase reverse transcriptase (TERT) that upregulates TERT transcription through activation of the MEK/ERK/AP-1 cascade. It induces TERT expression in WS fibroblasts (0.5 µM) and increases telomere synthesis in primary human cells. TAC alleviates neuroinflammation, increases neurotrophic factors, stimulates adult neurogenesis, and preserves cognitive function without toxicity in brain of naturally aged mice.
TAC (TERT activator compound) is a cell penetrant, selective and potent activator of telomerase reverse transcriptase (TERT) that upregulates TERT transcription through activation of the MEK/ERK/AP-1 cascade. It induces TERT expression in WS fibroblasts (0.5 µM) and increases telomere synthesis in primary human cells. TAC alleviates neuroinflammation, increases neurotrophic factors, stimulates adult neurogenesis, and preserves cognitive function without toxicity in brain of naturally aged mice.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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