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SML4298

STING degrader AK59

≥98% (HPLC)

Synonym(s):

AK59, AK59-51TB, N-(5-(pyridin-3-yl)quinolin-8-yl)-4-(trifluoromethyl)benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C21H14F3N3O2S
Molecular Weight:
429.41
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

STING degrader AK59 is a potent inhibitor of the cGAS/STING pathway (IC50 = 5.19 µM) by induction of STING interaction with ligase HERC4 (a HECT-domain E3 ligase) followed by degradation of STING. AK59 facilitates HERC4 to transfer ubiquitin directly to Lysine 150 of STING, which initiates the degradation. It is effective against wild-type STING and STING-associated vasculopathy (SAVI) mutant STING proteins in human CD14+ monocytic cells.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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