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About This Item
Empirical Formula (Hill Notation):
C19H16N5NaO7S3
CAS Number:
Molecular Weight:
545.54
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
General description
Ceftiofur sodium salt, a third-generation β-lactam antibiotic, exhibits broad-spectrum bactericidal activity against many veterinary pathogens.
potent, broad-spectrum β-lactam bactericidally inhibits bacterial cell wall synthesis via PBP binding, its active metabolite boosting veterinary efficacy and ensuring safety.
Ceftiofur sodium salt a third-generation β-lactam antibiotic, exhibits broad-spectrum bactericidal activity against many veterinary pathogens. Its core mechanism disrupts bacterial cell wall synthesis by irreversibly inactivating penicillin-binding proteins (PBPs) on the inner bacterial membrane, causing cell lysis. It shows potent activity with low MIC values against key pathogens like Pasteurella multocida (MIC90 ≤ 0.03 µg/ml) and Actinobacillus pleuropneumoniae (MIC90 ≤ 0.125 µg/ml). Parenterally administered due to poor oral absorption, ceftiofur rapidly metabolizes in vivo to desfuroylceftiofur (DFC), an equally active metabolite enhancing its efficacy. With a good therapeutic safety profile, ceftiofur is a significant veterinary antimicrobial for susceptible infections.
Ceftiofur sodium salt a third-generation β-lactam antibiotic, exhibits broad-spectrum bactericidal activity against many veterinary pathogens. Its core mechanism disrupts bacterial cell wall synthesis by irreversibly inactivating penicillin-binding proteins (PBPs) on the inner bacterial membrane, causing cell lysis. It shows potent activity with low MIC values against key pathogens like Pasteurella multocida (MIC90 ≤ 0.03 µg/ml) and Actinobacillus pleuropneumoniae (MIC90 ≤ 0.125 µg/ml). Parenterally administered due to poor oral absorption, ceftiofur rapidly metabolizes in vivo to desfuroylceftiofur (DFC), an equally active metabolite enhancing its efficacy. With a good therapeutic safety profile, ceftiofur is a significant veterinary antimicrobial for susceptible infections.
Application
Biochem/physiol Actions
Ceftiofur sodium salt disrupts bacterial cell wall synthesis by irreversibly inactivating penicillin-binding proteins (PBPs) on the inner bacterial membrane, causing cell lysis. It shows potent activity with low MIC values against key pathogens like Pasteurella multocida (MIC90 ≤ 0.03 µg/ml) and Actinobacillus pleuropneumoniae (MIC90 ≤ 0.125 µg/ml). Parenterally administered due to poor oral absorption, ceftiofur rapidly metabolizes in vivo to desfuroylceftiofur (DFC), an equally active metabolite enhancing its efficacy. With a good therapeutic safety profile, ceftiofur is a significant veterinary antimicrobial for susceptible infections.
Disclaimer
Hygroscopic Store with desiccant
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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