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Merck
CN

SML4306

4-Azido-L-phenylalanine hydrochloride

≥98% (HPLC)

Synonym(s):

(S)-2-Amino-3-(4-azidophenyl)propanoic acid hydrochloride, H-Phe(4-N3)-OH HCl, 4-Azidophenylalanine HCl, p-Azido-L-phenylalanine HCl, pAzF

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About This Item

Empirical Formula (Hill Notation):
C9H10N4O2·HCl
CAS Number:
Molecular Weight:
242.66
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
desiccated
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assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

Biochem/physiol Actions

4-Azido-L-phenylalanine (pAzF), an unnatural amino acid featuring a bioorthogonal azide handle, is site-specifically incorporated into proteins via genetic code expansion, providing a unique modification site. This incorporated azide enables precise attachment of probes (dyes, tags, therapeutics) through bioorthogonal click chemistry or photo-crosslinking, yielding proteins with novel functionalities for imaging, interaction studies, and creating biomaterials/bioconjugates. Consequently, 4-Azido-L-phenylalanine (pAzF) is a powerful tool in chemical biology and biotechnology for protein engineering, functional analysis, and therapeutic applications across diverse cellular systems.

Disclaimer

Hygroscopic, Store with desiccant

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