assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Application
Lipoamide may be used:
- as a small‑molecule antioxidant / neuroprotective agent (a neutral amide derivative of lipoic acid) to evaluate protection against oxidative‑stress‑induced neuronal cell damage
- as a stimulator of mitochondrial biogenesis in differentiated 3T3‑L1 adipocytes to explore potential benefits for metabolic dysfunction
- to study its effects on hypertensive myocardial hypertrophy using rat models
Biochem/physiol Actions
Lipoamide, a lipoic acid acting as a coenzyme for of enzymes involved in amino acid metabolism, is a well-tolerated modulator of stress granule condensation that specifically prevents cytoplasmic condensation of stress granule proteins. Lipoamide stabilizes intrinsically disordered domain-containing proteins, including SRSF1 and SFPQ, and reverses stress granule formation in vitro. Lipoamide ameliorates aging-associated aggregation of a stress granulereporter protein, improves neuronal morphology and recovers motor defects caused by amyotrophic lateral sclerosis (ALS)-associated FUS and TDP-43 mutants in fly (Drosophila melanogaster) models of ALS.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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