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About This Item
Empirical Formula (Hill Notation):
C29H23BrClN5O2
CAS Number:
Molecular Weight:
588.88
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
powder
Quality Segment
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
eIF4A3-IN-1 (Compound 53a) is a highly selective, cell-active inhibitor of eukaryotic initiation factor 4A3 (eIF4A3), exhibiting an ATPase IC50 of 0.26 µM and a KD of 0.043 µM. By directly binding a non-ATP site on eIF4A3, eIF4A3-IN-1 inhibits RNA-dependent ATPase activity while demonstrating excellent selectivity over related helicases eIF4A1, eIF4A2, DHX29, and BRR2 (all IC50 >100 µM). This targeted inhibition subsequently causes dose-dependent cellular suppression of nonsense-mediated RNA decay (NMD), affecting the stability of mRNAs with premature termination codons.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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