Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C29H23BrClN5O2
CAS Number:
Molecular Weight:
588.88
UNSPSC Code:
12352200
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
eIF4A3-IN-1 (Compound 53a) is a highly selective, cell-active inhibitor of eukaryotic initiation factor 4A3 (eIF4A3), exhibiting an ATPase IC50 of 0.26 µM and a KD of 0.043 µM. By directly binding a non-ATP site on eIF4A3, eIF4A3-IN-1 inhibits RNA-dependent ATPase activity while demonstrating excellent selectivity over related helicases eIF4A1, eIF4A2, DHX29, and BRR2 (all IC50 >100 µM). This targeted inhibition subsequently causes dose-dependent cellular suppression of nonsense-mediated RNA decay (NMD), affecting the stability of mRNAs with premature termination codons.
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service