SML4324
VS-4718
≥98% (HPLC)
Synonym(s):
2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide, 2-(2-(2-Methoxy-4-(4-morpholinyl)phenyl]amino)-5-(trifluoromethyl)pyridin-4ylamino)-N-methylbenzamide, PND-1186, PND 1186, PND1186, SR 2516, SR-2516, SR2516, VS 4718, VS4718
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About This Item
Empirical Formula (Hill Notation):
C25H26F3N5O3
CAS Number:
Molecular Weight:
501.50
UNSPSC Code:
12352200
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
PND-1186 is an orally available, potent and reversible inhibitor against focal adhesion kinase (FAK IC50 = 1.5 nM; 50 µM ATP) and FMS-like tyrosine kinase 3 (72% Flt3 & 62% FAK inhibition by 100 nM PND-1186) with much reduced or little potenty toward 32 other kinases. PND-1186 inhibits cellular FAK activation (FAK pY397 IC50 = 100 nM) and migration (by 45%; 1 µM PND-1186) in adherent murine breast carcinoma 4T1 cultures. PND-1186 suppresses 4T1 soft agar colony growth (0.1-1 µM) and murine ID8 ovarian carcinoma tumor growth in mice in vivo (0.5 mg/mL via drinking water with 5% sucrose).
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