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SML4329

MN551

≥98% (HPLC)

Synonym(s):

(S)-4-(3-((3-(2-Chloroacetamido)benzyl)amino)-2-(2-(4-fluorophenyl)acetamido)-3-oxopropyl)phenyl phosphoric acid, MN 551, MN-551

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About This Item

Empirical Formula (Hill Notation):
C26H26ClFN3O7P
Molecular Weight:
577.93
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

MN551 is an E3 ligase suppressor of cytokine signaling 2 (SOCS2) inhibitor that blocks SOCS2 substrate binding by covalently modifying SOCS2 SH2 domain EF loop Cys111. MN551 also effectively modifies SH2 containing protein (CISH) (Cys114), but not SOCS4 (Cys350) or SOCS6 (no EF loop Cys). Preincubation of K562 lysate with MN551 (1.5h at r.t.) blocks endogenous SOCS2 from binding immobilized GHR pY595 substrate peptide (IC50 = 5.9 µM).

Disclaimer

Hygroscopic Store with desiccant

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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