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SML4330

MN714

≥98% (HPLC)

Synonym(s):

(S)-4-(3-((3-(2-Chloroacetamido)benzyl)amino)-2-(2-(4-fluorophenyl)acetamido)-3-oxopropyl)phenyl dipivaloyloxymethyl phosphate, MN 714, MN-714

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About This Item

Empirical Formula (Hill Notation):
C38H46ClFN3O11P
Molecular Weight:
806.21
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

MN714 is a cell-permeable pivaloyloxymethyl (POM) ester precursor of MN551, an E3 ligase suppressor of cytokine signaling 2 (SOCS2) inhibitor. Upon entering cells, MN714 is hydrolyzed by cellular esterases to MN551 that covalently modifies SOCS2 SH2 domain EF loop Cys111. MN551 also effectively modifies SH2 containing protein (CISH) (Cys114), but not SOCS4 (Cys350) or SOCS6 (no EF loop Cys). MN714 treatment of K562 cells (10 µM for 6h) prior to lysate preparation compeletly abrogates endogenous SOCS2 binding of immobilized GHR pY595 substrate peptide.

Disclaimer

Hygroscopic, Store with desiccant

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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