Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C16H21NO2·HCl
CAS Number:
Molecular Weight:
295.80
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
CCI-38, a novel YTHDF2 inhibitor, exhibits high target affinity (KD: 10.1 µM) by competitively binding to its m6A/m5C pocket, specifically interacting with the unique C482 cysteine residue within YTHDF2; this interaction, coupled with its Michael acceptor moiety, drives its preferential selectivity over YTHDF1/3. CCI38 (IC50: 0.6-1.9 µM) destabilizes m5C-modified mRNA of ATP synthesis pathway genes, including ATP5PB/MF/MG, while upregulating m6A-modified mRNAs such as CD19/HLA-DMA/B, leading to reduced OXPHOS and reversed immune evasion. Furthermore, CCI-38 demonstrates in vivo efficacy in NSG mice xenografted with B-ALL, reducing tumor burden, prolonging survival, and sensitizing relapsed B-ALL to both CD19-CAR-T and blinatumomab with a dose of 0.25 mg/kg administered three times per week, making it a valuable candidate for enhancing T-cell immunotherapies.
Disclaimer
Hygroscopic, store with desiccant
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1B
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.