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About This Item
Empirical Formula (Hill Notation):
C30H27F3N6O
CAS Number:
Molecular Weight:
544.57
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
HSL119 is a cell penetrant, potent and selective inhibitor of HUNK kinase (hormonally upregulated neu-associated kinase) that completely blocks phosphorylation of the Rubicon S92 in vitro. HSL119 decreases Rubicon S92 phosphorylation and potently inhibits survival of patient driven JIMT-1 cells (HER2+ breast cancer cells) (IC50 = 1.7µM in JIMT-1 cells). HSL119 exhibits substantial efficacy toward HER2+ breast cancer. Additionally, HSL119 inhibits ABL1, BRAF, FLT3, and RET kinases.
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Repr. 1B - STOT RE 1 Dermal
Target Organs
Liver,Bone marrow,Pancreas,Cardio-vascular system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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