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About This Item
Empirical Formula (Hill Notation):
C16H12F3N5O4
Molecular Weight:
395.29
UNSPSC Code:
12352200
eCl@ss:
32160701
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
Biochem/physiol Actions
ALKBH1-IN-16 is a cell-permeant hydroxamate analog that effectively competes with α-KG to suppress ALKBH1 (KD = 3.27 µM and IC50 = 1.696 µM), a DNA demethylase. By engaging ALKBH1, ALKBH1-IN-16 prevents its interaction with DNA, increasing N6-Methyladenine (6mA) levels in cellular DNA and mimicking the effects of ALKBH1 suppression on gene regulation and signaling. Furthermore, ALKBH1-IN-16 inhibits the growth of U251 brain cancer cells (IC50 = 12.92 µM) and, at higher doses, targets COX-2, HDAC2, and HDAC7 (IC50 = 1.45, 8.74, and 18.62 µM, respectively), showcasing its wider inhibitory impact on enzymes linked to inflammation and gene expression.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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