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About This Item
Empirical Formula (Hill Notation):
C21H38IN5O6
CAS Number:
Molecular Weight:
583.46
UNSPSC Code:
12352200
Assay:
≥95%
Form:
powder
Storage condition:
desiccated, protect from light
Quality Segment
assay
≥95%
form
powder
storage condition
desiccated, protect from light
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Desthiobiotin polyethyleneoxide iodoacetamide (IA-DTB) is a precision chemical probe for activity-based protein profiling (ABPP) that excels in sophisticated systems, from the exofacial proteome of living cells to clinically relevant primary human cells. Its utility expands beyond quantifying reactive cysteines to mapping dynamic post-translational modifications (PTMs) like S-nitrosylation. The probe′s trifunctional architecture—a specific iodoacetamide warhead, a hydrophilic polyethyleneoxide linker, and a desthiobiotin tag—is optimized for enrichment and mass spectrometry-based identification. Its strategic value is fully realized in competitive profiling experiments, where the desthiobiotin tag′s moderate affinity for streptavidin allows for mild elution and maximal recovery of captured biomolecules. This feature makes it a cornerstone tool for defining the ′ligandable proteome′ and deconvoluting the mechanism of action for covalent therapeutics in physiologically relevant systems.
Disclaimer
Hygroscopic, Store with desiccant
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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