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Merck
CN

SML4401

5-TAMRA-PEG4-Alkyne

≥98% (HPLC)

Synonym(s):

5-Carboxytetramethylrhodamine, PEG4-Propargylamide, 9-[2-Carboxy-4-(1-oxo-5,8,11,14-tetraoxa-2-azaheptadec-16-yn-1-yl)phenyl]-3,6-bis(dimethylamino)-xanthylium inner salt, TAMRA-PEG4-Alkyne, TAMRA-5-PEG4-Alkyne, TAMRA-PEG4-Alkyne 5-isomer, TAMRA-(PEG)4-alkyne

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About This Item

Empirical Formula (Hill Notation):
C36H41N3O8
CAS Number:
Molecular Weight:
643.73
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, protect from light
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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

dark blue to very dark purple

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

5-TAMRA-PEG4-Alkyne (TAMRA-PEG4-Alkyne) is a high-precision bioorthogonal probe engineered for the specific, covalent labeling of azide-modified biomolecules. TAMRA-Alkyne integrates the bright, photostable 5-TAMRA fluorophore (λex/λem: ~555/580 nm) with a terminal alkyne for irreversible copper-catalyzed click chemistry. Its key strategic advantage lies in the bifunctional design, where an isomerically pure fluorophore ensures reproducibility and a hydrophilic PEG4 linker enhances aqueous solubility while minimizing non-specific background. This construct enables robust, high signal-to-noise visualization of metabolically incorporated tags in complex biological samples via microscopy and in-gel analysis, providing a versatile and reliable alternative to antibody-based detection methods for studying dynamic cellular processes.

Disclaimer

Hygroscopic, store with desiccant


Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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