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About This Item
Empirical Formula (Hill Notation):
C17H15N5O2
CAS Number:
Molecular Weight:
321.33
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
USP30-I-1 is a potent and selective cyanopyrrolidine-based covalent inhibitor of the mitochondrial deubiquitinase USP30, designed to enhance mitophagy by targeting the catalytic cysteine (Cys77) with high specificity at concentrations ≤1 μM. USP30-I-1 demonstrates dose-dependent inhibition with an IC50 of 94 nM in neuroblastoma cells, efficiently blocking USP30 activity with no significant toxicity reported in the tested models and no adverse effects on non-target proteins within the tested concentration range. USP30-I-1’s kinetic profile (kinact/KI = 0.18 μM⁻¹s⁻¹) highlights its effective covalent bond formation, while in vitro studies confirm its ability to disrupt ubiquitin-substrate interactions essential for mitophagy regulation.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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