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About This Item
Empirical Formula (Hill Notation):
C11H7F3N2O3
CAS Number:
Molecular Weight:
272.18
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
powder
Quality Segment
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Compound 20m potently inhibits RNA N⁶-methyladenosine (m⁶A) demethylase ALKBH5, with a fluorescence polarization assay IC₅₀ of 21 nM. Demonstrating high ALKBH5 selectivity, 20m shows minimal activity against FTO, ALKBH1, and ALKBH2 (IC₅₀ > 25 μM in DSF and FP assays). Cellular assays in HepG2 cells confirm 20m′s cell permeability and on-target demethylase activity, evidenced by ALKBH5 stabilization in cellular thermal shift assay and dose-dependent elevation of intracellular m⁶A levels. Molecular docking suggests inhibition occurs via 2-oxoglutarate binding pocket engagement, involving Mn(II) coordination, hydrogen bonds, and hydrophobic interactions.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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