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About This Item
Empirical Formula (Hill Notation):
C22H30N4O6
CAS Number:
Molecular Weight:
446.50
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
Biochem/physiol Actions
CAY10603, also known as BML-281 or Isox, is a highly selective HDAC6 inhibitor featuring an active site zinc-binding isoxazolo hydroxamate chelator, with IC50 values of 2.4 nM for HDAC6, 71 nM for HDAC1, and ~ 500 nM for HDAC10. CAY 10603 demonstrates significant anticancer potential, especially against pancreatic cancer cells with IC50 values below 0.5 μM, while also inhibiting tau deacetylation on KXGS motifs and Hedgehog signaling via Gli-dependent and independent pathways. CAY-10603 exhibits potent anti-inflammatory effects, suppressing inflammatory cascades and oxidative stress by modulating NF-κB and NLRP3 inflammasome pathways in various conditions.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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