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SML4434

SC912

≥98% (HPLC)

Synonym(s):

3,5-dichloro-N-(2-(3-(3-cyanophenyl)ureido)-5-(trifluoromethyl)phenyl)benzamide

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About This Item

Empirical Formula (Hill Notation):
C22H13Cl2F3N4O2
Molecular Weight:
493.27
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

SC912 is a cell penetrant, potent and selective pan- androgen receptor (AR) inhibitor that binds to full-length AR as well as AR-V7 through AR N-terminal domain (IC50 = 0.36 and 1.01 μM, AR-V7 and ARv567es respectively). SC912 disturbs AR-V7 transcriptional activity and impairs AR-V7 nuclear localization and DNA binding. SC912 potently inhibits proliferation, induced cell-cycle arrest, and apoptosis of AR-V7 positive castration-resistant prostate cancer (CRPC) cells. It also inhibits growth of AR-V7 expressing CRPC xenografts.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H317

Hazard Classifications

Skin Sens. 1B

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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