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Merck
CN

SML4446

LDM

≥98% (HPLC)

Synonym(s):

DCOH-FR-Ocl, LDM lipid droplet probe, O-[4-[2-[3-(Dicyanomethylene)-5,5-dimethyl-1-cyclohexen-1-yl]ethenyl]phenyl] N,N-dimethylcarbamothioate

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About This Item

Empirical Formula (Hill Notation):
C22H23N3OS
CAS Number:
Molecular Weight:
377.50
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

LDM is a cell penetrant lipid droplets fluorescent probe that selectively visualize the neutral lipid core of lipid droplets (LDs). LDM is activated by the HClO/ClO- present in the lipid droplets microenvironment to generate LDM-OH which selectively visualizes lipid droplet (LD) membrane by binding to LD associated proteins through electrostatic interactions. The HClO/ClO- activation transforms the green fluorescent pro-probe LDM (emission at 522 nm) to a red fluorescent LDM-OH (far-red emission at 637 nm). Also LDM (DCOH-FR-OCl) can be effectively utilized in the real-time imaging of endogenous and exogenous OCl- in living cells.


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Acute Tox. 4 Oral - Skin Irrit. 2

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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