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About This Item
Empirical Formula (Hill Notation):
C17H20N2O2
Molecular Weight:
284.35
UNSPSC Code:
12352200
Assay:
≥97% (NMR)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥97% (NMR)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
: L10 is a blood-brain barrier-permeable imine chelator that corrects copper dyshomeostasis in Alzheimer′s disease (AD) by targeting the pathogenic Cu-Aβ complex. L10 demonstrates functional efficacy by extracting nearly all Cu(II) from this complex in vitro at a 3:1 molar ratio. In a rat AD model, this mechanism translates to significant neuroprotection, marked by reduced neuroinflammation, oxidative stress, and Aβ accumulation in the hippocampal CA3. This targeted activity restores ATP7B transporter function and boosts BDNF expression, leading to a robust recovery of spatial memory. Distinguished by an excellent safety profile (EC50 = 914.3 µM) and optimized lipophilicity (LogP = 2.94), L10 is a compelling candidate for a disease-modifying AD therapy.
Disclaimer
Hygroscopic, Store with desiccant
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2 - Skin Sens. 1B
Storage Class
11 - Combustible Solids
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