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SML4482

AF64394

≥97% (HPLC)

Synonym(s):

N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

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About This Item

Empirical Formula (Hill Notation):
C21H20ClN5O
CAS Number:
1637300-25-4
Molecular Weight:
393.87
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
powder
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Quality Segment

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

AF64394 is a potent and selective inverse agonist for the G protein-coupled receptor GPR3 (IC50 = 0.5 µM GPR3, 7.9 µM GPR6 and 12 µM GPR12) that potently inhibits cAMP accumulation in HEK293 cells. It appears that AF64394 binds to the transmembrane dimer interface and functions as a negative allosteric modulator (NAM) specifically targeting dimeric GPR3.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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