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About This Item
Empirical Formula (Hill Notation):
C45H73NO15
CAS Number:
Molecular Weight:
868.06
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Solamargine, a pharmacologically versatile steroidal glycoalkaloid, exhibits potent anticancer activity (IC₅₀ 0.91–20 µM) and reverses multidrug resistance by inhibiting P-glycoprotein. Solamargine’s pleiotropic action is defined by a multi-pronged mechanism that induces apoptosis via extrinsic (TNFR/Fas)/intrinsic (Bcl-2/Bax) pathways while suppressing pro-survival (STAT3, PI3K/Akt) and metastatic signaling, potentially guided by selective RBL receptor uptake. This versatility extends to distinct antiviral and anti-inflammatory roles, exemplified by Solamargine’s ability to inhibit HBV replication through MZF1 protein interaction and suppress skin inflammation via the p38 MAPK pathway.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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