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About This Item
Empirical Formula (Hill Notation):
C37H44O4P·CH3O3S
CAS Number:
Molecular Weight:
678.81
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
oil
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
oil
storage condition
desiccated
color
faint orange to red
storage temp.
-10 to -25°C
Biochem/physiol Actions
Mitoquinone mesylate (MitoQ), a TPP-CoQ10 conjugate, selectively accumulates 1,000-fold in the mitochondrial matrix via membrane potential (ΔΨm), redox cycling ubiquinol to ubiquinone, reducing ROS, upregulating endogenous antioxidants. Targeted delivery confers ~800-fold greater efficacy than untargeted antioxidants in preventing cell death, exhibiting antiproliferative effects in cancer (IC50s: 0.38 µM proliferation, 0.52 µM complex I inhibition). MitoQ provides systemic benefits (improved vascular/metabolic function, reduced liver inflammation/fibrosis), demonstrating chondrocyte cytotoxicity (1.094 mM) and efficacy in canine mammary gland tumor cells, offering a superior strategy combating organelle-specific oxidative stress and dysfunction across pathologies.
Disclaimer
Hygroscopic, Store with desiccant
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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