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SRP0342

cKit active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥32% (SDS-PAGE)

Synonym(s):

CD117, KIT, PBT, SCFR, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

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About This Item

CAS Number:
1537224-27-3
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
aqueous solution
Assay:
≥32% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
53.5 kDa

Key Documents

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Product Name

cKit active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥32% (SDS-PAGE)

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥32% (SDS-PAGE)

form

aqueous solution

mol wt

53.5 kDa

packaging

pkg of 10 μg

technique(s)

activity assay: suitable
inhibition assay: suitable

NCBI accession no.

NM_000222

UniProt accession no.

P10721

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... KIT(3815)

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

General description

Human cKit (D816V) ( GenBank Accession No. NM_000222), amino acids 544-end with N-terminal His-tag, MW=50 kDa, expressed in an Baculovirus infected Sf9 cell expression system.

Physical form

Fomulated in 25 mM Tris-HCl, pH 8.0, 138 mM NaCl, 0.05% Tween-20, 3 mM DTT and 10% glycerol.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
4025210831

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Mauro Picardo et al.
The Journal of investigative dermatology, 131(6), 1182-1185 (2011-05-14)
Cutaneous pigmentation is regulated by a complex melanogenic network in which skin cells synthesize growth factors and cytokines. Mutations in genes encoding these regulators modify their expression and/or functionality, leading to altered signaling pathways and contributing to altered skin phenotypes.
Y Yarden et al.
The EMBO journal, 6(11), 3341-3351 (1987-11-01)
Structural features of v-kit, the oncogene of HZ4 feline sarcoma virus, suggested that this gene arose by transduction and truncation of cellular sequences. Complementary DNA cloning of the human proto-oncogene coding for a receptor tyrosine kinase confirmed this possibility: c-kit

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