SRP0346
EphB2 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)
Synonym(s):
CAPB, DRT, EK5, EPH receptor B2, ERK
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥80% (SDS-PAGE)
form
aqueous solution
mol wt
52 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
0.5 mg/mL
technique(s)
activity assay: suitable
inhibition assay: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... EPHB2(2048)
General description
Human EPHB2 ( GenBank Accession No. NM_004442), amino acids 569-end with N-terminal His-tag, MW=52 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Hongshi Xu et al.
American journal of physiology. Renal physiology, 288(4), F855-F866 (2004-11-25)
EphA2, a member of the large family of Eph receptor tyrosine kinases, is highly expressed in epithelial tissue and has been implicated in cell-cell and cell-matrix interactions, as well as cell growth and survival. Expression of EphA2 mRNA and protein
Madhu Macrae et al.
Cancer cell, 8(2), 111-118 (2005-08-16)
The EphA2 receptor tyrosine kinase is frequently overexpressed in many cancers, including 40% of breast cancers. Here, we show that EphA2 is a direct transcriptional target of the Ras-Raf-MAPK pathway and that ligand-stimulated EphA2 attenuates the growth factor-induced activation of
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