SRP0385
MLL1/WDR5/Ash2L/RbBP5 human
recombinant, expressed in E. coli, ≥83% (SDS-PAGE)
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in E. coli
Assay
≥83% (SDS-PAGE)
form
aqueous solution
mol wt
27 kDa (MLL1)
35 kDa (WDR5)
60 kDa (RbBP5)
61 kDa (Ash2L)
packaging
pkg of 50 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ASH2L(9070), MLL(4297), RBBP5(5929), WDR5(11091)
General description
MLL1/WAR complex of human MLL1 (GenBank Accession No. NM_005933), amino acids 3745- end with N-terminal His-tag, MW= 27 kDa, human Ash2L (GenBank Accession No. NM_001105214), amino acids 2-end with N-terminal His-tag, MW= 61 kDa, and human RbBP5 (GenBank Accession No. NM_005057), amino acids 2-end with N-terminal His-tag, MW= 60 kDa, individually expressed in an E. coli expression system, and human WDR5 (GenBank Accession No. NM_017588), amino acids 2-end with N-terminal His-tag, MW= 37.4 kDa expressed in a Baculovirus Sf9 expression system.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Man Mohan et al.
Nature reviews. Cancer, 10(10), 721-728 (2010-09-17)
The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined. It was therefore proposed that the regulation of the elongation stage of transcription could
Anamika Patel et al.
The Journal of biological chemistry, 284(36), 24242-24256 (2009-06-27)
Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of H3K4 methyltransferases and is frequently rearranged in acute
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