SRP0439
PrCP active human
recombinant, expressed in FreeStyle™ 293-F cells, ≥15% (SDS-PAGE)
Synonym(s):
HUMPCP, PCP, prolylcarboxypeptidase
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in FreeStyle™ 293-F cells
Assay
≥15% (SDS-PAGE)
form
aqueous solution
mol wt
53 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
0.06 mg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PRCP(5547)
General description
Human recombinant Lysosomal Pro-X carboxypeptidase, also known as angiotensinase C (GenBank Accession No. NM_005040) amino acids 31-496 with C-terminal His-tag, MW=53 kDa, expressed in HEK293 cells.
Application
Useful for the cleavage of C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin.
Legal Information
FreeStyle is a trademark of Invitrogen Corp.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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F Tan et al.
The Journal of biological chemistry, 268(22), 16631-16638 (1993-08-05)
Prolylcarboxypeptidase, a lysosomal serine carboxypeptidase, cleaves COOH-terminal amino acids linked to proline, as in angiotensin II and III and [des-Arg9] bradykinin. About 25% of the enzyme protein was sequenced, and the complete sequence was deduced from its human kidney cDNA.
New enzymatic route for the inactivation of angiotensin.
H Y Yang et al.
Nature, 218(5148), 1224-1226 (1968-06-29)
Lin Wang et al.
American journal of obstetrics and gynecology, 195(1), 162-171 (2006-05-10)
Renin-angiotensin System is essential for the homeostasis of blood pressure in humans. The roles of renin-angiotensin system gene polymorphisms including angiotensinogen, angiotensin-converting enzyme, renin and angiotensin II receptor, type 1 genes in the pathogenesis of preeclampsia have been extensively studied
Ok Jeong Moon et al.
Advanced healthcare materials, 11(15), e2200765-e2200765 (2022-06-08)
Cancer chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine, which are mostly small synthetic molecules, are still clinically useful for cancer treatment. However, despite considerable therapeutic efficacy, severe toxicity-associated problems, which are mainly caused by the non-specific mode of
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