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SRP0464

Sigma-Aldrich

BRD4, BD1, BD2 (49-460) His tag human

recombinant, expressed in E. coli, ≥75% (SDS-PAGE)

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Synonym(s):
CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥75% (SDS-PAGE)

form

aqueous solution

mol wt

47.5 kDa

packaging

pkg of 100 μg

NCBI accession no.

NM_058243

UniProt accession no.

O60885

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... BRD4(23476)

General description

Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_058243) amino-acids 49-460 with N-terminal His-tag, MW = 47.5 kDa, expressed in an E. coli expression system.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Philipp Voigt et al.
Genome biology, 12(11), 133-133 (2011-12-01)
The chromatin adapter BRD4 may be crucial for transmitting epigenetic information by acting as a histone acetylation-dependent gene bookmark and accelerating post-mitotic transcriptional reactivation.
R M Rodriguez et al.
Journal of molecular medicine (Berlin, Germany), 90(5), 587-595 (2011-11-29)
The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human

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