SRP0474
ATAD2A (981-1108) human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
ANCCA, ATPase family, AAA domain containing 2, PRO2000
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
aqueous solution
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
16.2 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
aqueous solution
mol wt
16.2 kDa
packaging
pkg of 100 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ATAD2(29028)
General description
Human Bromodomain ATAD2A (GenBank Accession No. NM_014109) amino acids 981 – 1108 with N-terminal HIS-tag, MW = 16.2 kDa, expressed in an E. coli expression system.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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C Caron et al.
Oncogene, 29(37), 5171-5181 (2010-06-29)
Cancer cells frequently express genes normally active in male germ cells. ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly expressed in testis as
Ekaterina V Kalashnikova et al.
Cancer research, 70(22), 9402-9412 (2010-09-25)
Chromatin coregulators are important factors in tumorigenesis and cancer progression. ANCCA is an AAA+ ATPase and a bromodomain-containing nuclear coactivator for the estrogen and androgen receptors that is crucial for assembly of chromatin-modifying complexes and proliferation of hormone-responsive cancer cells.
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