SRP2082
WT-1 (+KTS) human
recombinant, expressed in insect cells, ≥60% (SDS-PAGE)
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About This Item
NACRES:
NA.26
UNSPSC Code:
12352200
Form:
frozen liquid
Assay:
≥60% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in insect cells
biological source
human
recombinant
expressed in insect cells
assay
≥60% (SDS-PAGE)
form
frozen liquid
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
150 μg/mL
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... WT1(7490)
Biochem/physiol Actions
WT-1, the product of Wilms′ tumor suppressor gene Wt1, is a nuclear protein with structural motifs characteristic of transcription factors, including four C-terminal zinc fingers. While different pre-mRNA processing could result in 16 isoforms of the protein, the inclusion or exclusion of exon 5 and three amino acids (KTS) between zinc fingers 3 and 4 largely affects the activity of the WT1 protein. Such a complex post-transcriptional regulation, particularly in splicing, may represent a major regulatory mechanism for tumorigenesis of the Wilms′ tumor. With the inclusion of exon 5, WT1 (KTS+) binds to both DNA and RNA and is RNase but not DNase sensitive. This form also co-localizes with splicing factors in a speckled nuclear particle, suggesting that the WT1 protein may function as both a transcription factor and a splicing regulator.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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