SRP2085
BCL-10 human
recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
Synonym(s):
CARMEN, CIPER, CLAP, c-E10, mE10
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About This Item
NACRES:
NA.26
UNSPSC Code:
12352202
Biological source:
human
Recombinant:
expressed in insect cells
Assay:
≥80% (SDS-PAGE)
Form:
frozen liquid
Mol wt:
~28 kDa
biological source
human
recombinant
expressed in insect cells
assay
≥80% (SDS-PAGE)
form
frozen liquid
mol wt
~28 kDa
packaging
pkg of 6 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
250 μg/mL
color
clear, colorless
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... BCL10(8915)
Biochem/physiol Actions
Bcl-10 is an intracellular signaling protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas. The human Bcl10 gene encodes a protein of 233 amino acids containing an N-terminal caspase recruitment domain (CARD) that mediates self-oligomerization and the C-terminal region of Bcl-10. Bcl 10 is expressed ubiquitously with high expression levels in lymphoid tissues and in the developing central nerve system. Mutations have been found in cases of follicular lymphoma and diffuse large B cell lymphoma. Bcl-10 is a positive regulator of antigen-receptor induced NF-kB activation and Bcl-10-initiated activation of NF-kB can be inhibited by cotransfection of dominant-negative mutants of TRAF2, NIK, IKKa or IkBa.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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