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Merck
CN

SRP2104

Arginine Splicing Factor, His tagged human

recombinant, expressed in insect cells, ≥85% (SDS-PAGE)

Synonym(s):

ASF, FLJ53078, MGC5228, SF2, SF2p33, SFRS1, SRp30a

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About This Item

NACRES:
NA.26
UNSPSC Code:
12352202
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biological source

human

recombinant

expressed in insect cells

assay

≥85% (SDS-PAGE)

form

frozen liquid

mol wt

~29.3 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

350 μg/mL

color

clear, colorless

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SRSF1(6426)

Biochem/physiol Actions

ASF also known as SF2 is a member of the SR protein family. It is an essential pre-mRNA splicing factor required for both single and alternative splicing. Phosphorylation on serine residues located within the SR domain directly regulates ASF/SF2 activity and compartmentalization of other SR splicing factors. In addition to interacting with RNA and other splicing factors, such as U1-70K, U2AF and other SR proteins, ASF/SF2 also directly or indirectly interacts with HIV regulatory protein Rev, the C-terminal domain (CTD) of the largest subunit of RNA polymerase II, and numerous transcription factors, thereby suggesting a potential role of ASF/SF2 in coordinating transcription and pre-mRNA splicing.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.


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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



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