SRP2146
CAR, GST tagged, human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Synonym(s):
CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
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About This Item
NACRES:
NA.26
UNSPSC Code:
12352202
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥70% (SDS-PAGE)
Form:
frozen liquid
Mol wt:
~66.3 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥70% (SDS-PAGE)
form
frozen liquid
mol wt
~66.3 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
350 μg/mL
color
clear, colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... NR1I3(9970)
Biochem/physiol Actions
The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively acitve, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Storage Class
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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