SRP3203
IFN-lambda 2 from mouse
≥98% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized suitable for cell culture
Synonym(s):
IL-28A
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
≥98% (HPLC), ≥98% (SDS-PAGE)
Form:
lyophilized
Mol wt:
19.8 kDa
Impurities:
<0.1 EU/μg endotoxin, tested
Product Name
IFN-lambda 2 from mouse, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
mol wt
19.8 kDa
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... IL28A(338374)
Biochem/physiol Actions
IFN-λ 2 (Ifnl2) belongs to the type III interferon (IFN-λ) family of proteins. It is associated with antiviral, antitumor and immune activities. In a retinal autoimmunity mouse model, Ifnl2 increases the autoimmune disease. Ifnl2 signals via IFN (interferon)-λ receptor complex consisting of IL-10Rβ (interleukin 10 receptor β) and the IL-28Rα chains. The signaling pathway involves JAK1 (Janus kinase 1)/TYK2 (non-receptor tyrosine-protein kinase) tyrosine kinases, transcription factor complex IFN-stimulated gene factor 3 containing STAT1 (signal transducer and activator of transcription 1), STAT2 and IFN regulatory factor (IRF)-9.
Recombinant murine IFN-l2 is a 19.8kDa protein containing 175 amino acid residues.
Recombinant murine IFN-l2 is a 19.8kDa protein containing 175 amino acid residues.
Physical form
Lyophilized from 20 mM Sodium Phosphate, pH 7.5.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Other Notes
MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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