SRP3216
KC (CXCL1) from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym(s):
CXCL1, GRO1, GROa, NAP-3
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥98% (HPLC)
≥98% (SDS-PAGE)
≥98% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in E. coli
Mol wt:
7.8 kDa
Product Name
KC (CXCL1) from mouse, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
7.8 kDa
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
off-white to yellow
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... CXCL1(14825)
Physical form
Lyophilized with no additives.
Application
C-X-C motif chemokine receptor 1 (CXCL1) from mouse has been used in transwell assay for chemotaxis.
Biochem/physiol Actions
All three isoforms of growth-related protein (GRO) are CXC chemokines that can signal through C-X-C motif chemokine receptors 1 or 2 (CXCR1 or 2). The GRO proteins chemoattract and activate neutrophils and basophils. It has a role in host defense against polymicrobial sepsis, upregulation of intercellular adhesion molecule 1 (ICAM-1) and migration of neutrophils. The protein also activates mitogen-activated protein kinases (MAPKs), pro-inflammatory proteins and nuclear factor-κB (NF-κB).
General description
C-X-C motif chemokine receptor 1 (CXCL1) is also known as keratinocyte-derived chemokine (KC). It is part of the glutamate-leucine-arginine (ELR)-containing CXC chemokine family. Recombinant Murine KC (CXCL1) is a 7.8kDa protein consisting of 72 amino acids including the ‘ELR′ motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
Other Notes
APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle.
Pedersen L
American Journal of Physiology. Endocrinology and Metabolism, 302(7), E831-E840 (2012)
GRO: a novel chemotactic cytokine.
R Sager et al.
Advances in experimental medicine and biology, 305, 73-77 (1991-01-01)
CXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions.
Jin L
Journal of Immunology, 193(7), 3549-3558 (2014)
P Tekamp-Olson et al.
The Journal of experimental medicine, 172(3), 911-919 (1990-09-01)
A cDNA clone of murine macrophage inflammatory protein 2 (MIP-2) has been isolated from a library prepared from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the nucleotide sequence determined. This cDNA was used to clone cDNAs for human homologues of MIP-2
S Haskill et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(19), 7732-7736 (1990-10-01)
The product of the human GRO gene is a cytokine with inflammatory and growth-regulatory properties; GRO is also called MGSA for melanoma growth-stimulatory activity. We have identified two additional genes, GRO beta and GRO gamma, that share 90% and 86%
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