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SRP3289

Sigma-Aldrich

IL-36 GAMMA human

≥95% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized

Synonym(s):

IL-1ε, IL-1F, IL-1H1

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10 μG
CN¥2,531.95

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

CN¥2,531.95

Estimated to ship onDecember 08, 2025Details

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Product Name

IL-36 GAMMA human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

17.0 kDa

packaging

pkg of 10 μg

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

Q9NZH7

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SRP3288SRP6199SRP3320
IL-36 GAMMA human recombinant, expressed in E. coli, &#8805;95% (SDS-PAGE), &#8805;95% (HPLC)

Sigma-Aldrich

SRP3289

IL-36 GAMMA human

IL-36 BETA human recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC)

Sigma-Aldrich

SRP3288

IL-36 BETA human

IL-36&#946; human recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE)

Sigma-Aldrich

SRP6199

IL-36β human

IL-36RA human recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC)

Sigma-Aldrich

SRP3320

IL-36RA human

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

form

lyophilized

form

lyophilized

form

lyophilized powder

form

lyophilized

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

Q9NZH7

UniProt accession no.

Q9NZH8

UniProt accession no.

Q9UBH0

UniProt accession no.

Q9UBH0

General description

IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells.

Biochem/physiol Actions

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 7.0 + 50 mM NaCl.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0612544
    0911544

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    IL-36 BETA human recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC)

    Sigma-Aldrich

    SRP3288

    IL-36 BETA human

    Dinarello, C. et al.
    Nature Immunol., 11, 973-973 (2010)

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