SRP3289
IL-36 GAMMA human
≥95% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized
Synonym(s):
IL-1ε, IL-1F, IL-1H1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥95% (HPLC), ≥95% (SDS-PAGE)
Form:
lyophilized
Mol wt:
17.0 kDa
Impurities:
<0.1 EU/μg endotoxin, tested
Product Name
IL-36 GAMMA human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
biological source
human
recombinant
expressed in E. coli
assay
≥95% (HPLC), ≥95% (SDS-PAGE)
form
lyophilized
mol wt
17.0 kDa
packaging
pkg of 10 μg
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL36B(27177)
General description
IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells.
Biochem/physiol Actions
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.
Physical form
Lyophilized from 10 mM Sodium Phosphate, pH 7.0 + 50 mM NaCl.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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